She began her career as a big band singer in 1939, achieving commercial success in 1945 with two No. 1 recordings, “Sentimental Journey” and “My Dreams Are Getting Better All the Time” with Les Brown and His Band of Renown. She left Brown to embark on a solo career and recorded more than 650 songs from 1947 to 1967.
Her film career began with Romance on the High Seas (1948). She starred in films of many genres, including musicals, comedies, dramas and thrillers. She played the title role in Calamity Jane (1953) and starred in Alfred Hitchcock’s The Man Who Knew Too Much (1956) with James Stewart. She costarred with Rock Hudson in three successful comedies including Pillow Talk (1959), for which she was nominated for the Academy Award for Best Actress. She also worked with James Garner on both Move Over, Darling (1963) and The Thrill of It All (1963) and starred alongside Clark Gable, Cary Grant, James Cagney, David Niven, Ginger Rogers, Jack Lemmon, Frank Sinatra, Kirk Douglas, Lauren Bacall, and Rod Taylor in various films. After ending her film career in 1968, only briefly removed from the height of her popularity, she starred in her own television sitcom The Doris Day Show (1968–1973).